March 2019: Selective Progesterone Receptor Modulates (SPRM) for the treatment of heavy bleeding associated with fibroids

Journal Club Global

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Sukhbir Singh, M.D., Christian Seitz, M.D., and and Kathrin Petersdorf, M.D., are joined by experts in the field including William Catherino, M.D., Ph.D., and David Archer, M.D., to discuss their recent Fertility and Sterility manuscript, "Vilaprisan in women with uterine fibroids: the randomized phase 2b ASTEROID 1 study." Questions and issues addressed include:

  • What is the mechanism of action of a SPRM on fibroid-related symptoms?
  • What is the expected reduction in bleeding that can be expected with Vilaprisan treatment?
  • What are the expected side effects and safety of treatment? 
  • What are the challenges in the conduct of a multicenter RCT accessing a new therapy?
  • What is expected for the future in regards to the development of SPRM and a clinical therapy?

This Journal Club Global is hosted by Richard Burney, M.D., and the Reproductive Endocrinology and Infertility fellowship at Madigan Army Medical Center. The event is moderated by Fertility and Sterility's Video and Media Editor, Kurt Barnhart, M.D., M.S.C.E.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.