Children born to women with polycystic ovary syndrome—short- and long-term impacts on health and development
Maternal polycystic ovary syndrome (PCOS) may impair offspring growth, cardiometabolic and reproductive health, and neurodevelopment. There is an urgent need for large-scale international studies on children born to women with PCOS.
Volume 111, Issue 6, Pages 1065–1075
Eszter Vanky, M.D., Ph.D., Liv Guro Engen Hanem, M.D., David H. Abbott, Ph.D.
Maternal PCOS status may negatively influence offspring infant and childhood growth, cardiometabolic health, reproductive health, and neurodevelopment. Current findings across studies are divergent, often because of small numbers of subjects, as well as heterogeneous selection criteria, ethnicities, and definitions of control groups. Coexisting maternal obesity, pregnancy complications, and comorbidity make it difficult to identify the contribution of maternal PCOS. Large, prospective, international, multiethnic studies with standardized investigation protocols and questionnaires on PCOS offspring health and development are needed.