Prewash total motile count is a poor predictor of live birth in intrauterine insemination cycles
Prewash total motile count is a poor predictor of live birth in IUI cycles. Women older than 37 years have a decreased live birth rate with IUI.
Volume 111, Issue 4, Pages 708–713
Erin B. Mankus, M.D., Alan E. Holden, Ph.D., Paige M. Seeker, M.D., Jordan C. Kampschmidt, B.A., Jessica E. McLaughlin, M.D., Robert S. Schenken, M.D., Jennifer F. Knudtson, M.D.
To determine whether there is a relationship between prewash total motile count and live births in couples undergoing IUI.
Retrospective review in a single academic center.
Couples with infertility undergoing ovulation induction with IUI between 2010 and 2014.
Main Outcome Measure(s)
Our cohort included 310 women who underwent 655 IUI cycles with a cumulative live birth rate (LBR) per couple of 20% and an LBR per cycle of 10%. A analysis yielded no correlation between prewash total motile count (TMC) and live births. No live births occurred with TMC <2 million sperms. Age had a significant negative relationship to LBR. A receiver operating characteristic analysis comparing age and live births indicated a significant decline in live births for women >37 years (90% sensitivity, 70% specificity). The LBR per couple was decreased to 7% in women >37 years compared with 25% in women <37 years.
Prewash TMC is a poor predictor of live birth. There were no live births with prewash TMC <2 million sperms. The LBR for women >37 years with IUI was significantly lower than women <37 years.