Outcome of ovarian stimulation for oocyte cryopreservation in women with Turner syndrome

Oocyte cryopreservation after ovarian stimulation appears to be safe and successful in women with mosaic Turner syndrome who wish to consider fertility preservation.

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Fertility and Sterility
Editorial Office, American Society for Reproductive Medicine
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Volume 111, Issue 3, Pages 505–509

Authors:

Vikram Sinai Talaulikar, Ph.D., Gerard S. Conway, Ph.D., Antoinette Pimblett, M.Sc., Melanie C. Davies, M.A.

Abstract:

Objective

To study the safety and efficacy of ovarian stimulation and oocyte cryopreservation as a method of fertility preservation in women with Turner syndrome (TS).

Design

Retrospective cohort study.

Setting

Reproductive medicine clinic.

Patient(s)

Seven women with TS who attended the clinic between 2011 and 2017.

Intervention(s)

Ovarian stimulation and oocyte cryopreservation.

Main Outcomes Measure(s)

Number of oocytes cryopreserved, ovarian hyperstimulation syndrome.

Result(s)

The oocyte retrieval rates (mean ± SD, 9 ± 3.16) in women with TS were comparable to the published data from healthy women. The oocyte yield was higher than expected based on the low antimüllerian hormone levels. There was no correlation between baseline antimüllerian hormone or antral follicle count levels and the number of oocytes retrieved.

Conclusion(s)

Oocyte cryopreservation after ovarian stimulation appears to be safe and successful in women with mosaic TS who wish to consider fertility preservation.



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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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