Oocyte donation: lessons from the past, directions for the future

Oocyte donation has extended the advances of assisted reproduction and has helped thousands of couples with ovarian dysfunction. It has also provided us with unique scientific insights, which are discussed.

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Volume 110, Issue 6, Pages 979–980


Steven R. Lindheim, M.D., M.M.M., Susan C. Klock, Ph.D.


Oocyte donation has its origins in the clandestine use of donated sperm more than 140 years ago. Since first described in 1983, oocyte donation has resulted in more than 50,000 births in the United States alone and today now accounts for more than 10% of all IVF cycles performed yearly in the United States. The use of donated oocytes has changed the human reproductive landscape, challenging the traditional norms of conception and parenthood. Oocyte donation has also provided a unique scientific model that separates the egg from the uterus, allowing the independent study of each in normal physiologic and pathological conditions and providing insights into the fundamental aspects of reproduction, cell biology, and genetics. This Views and Reviews takes us through the historical development of oocyte donation, its scientific insights, and its application to daily practice and management, as well as insights into what the future may hold for this field.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. 


Go to the profile of Steven R. Lindheim, MD, MMM
about 3 years ago

I thank F&S the opportunity to collaborate with the pioneers in the field who have added both scientific and clinical advances in assisting many families fulfill their dreams.

Go to the profile of Micah J Hill
about 3 years ago

Thank you Steven and all the other pioneers for this wonderful edition.  Ill be tracking you all down to autograph my print version.  This is a keeper!