Volume 110, Issue 7, Pages 1227–1230
Wellington P. Martins, M.D., Ph.D., Craig Niederberger, M.D., Carolina O. Nastri, M.D., Ph.D., Catherine Racowsky, Ph.D.
When deciding whether to use a medical intervention, evidence regarding not only effectiveness but also safety and costs must be weighed. Indeed, providing these three cornerstones of evidence is the main task of clinical researchers in any field. In reproductive medicine, although there is a good and long-lasting discussion regarding what is the best outcome for assessing effectiveness (1), safety and particularly costs are frequently overlooked.