Male infertility as a window to health

Male infertility may be a harbinger of future health. Associations may arise from genetic, developmental, and lifestyle factors. Male infertility may be associated with chronic medical conditions, hospitalization, and mortality.

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Volume 110, Issue 5, Pages 810–814


Jeremy T. Choy, M.D., Michael L. Eisenberg, M.D.


There is an emerging body of evidence suggesting that male infertility may be a harbinger of future health. Potential associations between infertility and health may arise from genetic, developmental, and lifestyle factors. Studies have explored possible links between male infertility and oncologic, cardiovascular, metabolic, and autoimmune diseases. Male infertility may also be a predictor of hospitalization and mortality. Additional research is required to elucidate the mechanisms by which male infertility affects overall health.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.


Go to the profile of Jim Dupree
over 2 years ago

I applaud the authors for their expert review of this important topic.  What investments do we need to make to get to the underlying cause of these findings?  Are there key basic science or epidemiological  infrastructures that should be built?  As the authors conclude, there are key unanswered question that we must address to better understand what is happening to these men and how to improve their reproductive and overall health.