The role of immunotherapy in in vitro fertilization and recurrent pregnancy loss: a systematic review and meta-analysis
This study did not show a role for immunotherapy in women undergoing in vitro fertilization treatment or for prevention of recurrent pregnancy loss; therefore it should currently not be used in routine clinical practice.
Volume 110, Issue 6, Pages 1089–1100
Chiara Achilli, M.D., Montserrat Duran-Retamal, M.D., Wael Saab, M.R.C.O.G, Paul Serhal, M.R.C.O.G, Srividya Seshadri, M.D.
To study the current evidence on the role of immunotherapy in IVF and in the management of recurrent pregnancy loss (RPL).
Systematic review and meta-analysis.
A literature search was performed using MEDLINE, PUBMED, CINAHL, and EMBASE until May 2017. Only randomized controlled trials were included, and a meta-analysis was carried out where appropriate.
Women undergoing IVF treatment with or without a history of recurrent implantation failure and women with idiopathic RPL.
Assessment of the efficacy of commonly used immunomodulators such as IV use of  immunoglobulin,  lymphocyte immunotherapy and  intralipid; intrauterine infusion of  granulocyte colony-stimulating factor and  peripheral blood mononuclear cells; subcutaneous administration of  TNF-alpha inhibitors,  leukaemia inhibitory factor; and oral administration of  glucocorticoids.
Main Outcome Measure(s)
The primary outcomes were live birth rate and miscarriage rate; secondary outcome was clinical pregnancy rate.
Of the 7,226 publications identified, 53 were selected during the initial screening; 30 satisfied the selection criteria and were included in this review.
The available medical literature shows controversial results about the role of immunotherapy when used for improving reproductive outcomes. This study did not show a role for immunotherapy in improving the live birth rate in women undergoing IVF treatment or in the prevention of idiopathic RPL. Currently, immunotherapy should be used in the context of research and should not be used in routine clinical practice to improve reproductive outcomes.