VOLUME 118, ISSUE 2, P247-248
Anuja Dokras, M.D., M.H.C.I., Ph.D.
This year, Louise Brown celebrates her 44th birthday. Since the birth of the first in vitro fertilization (IVF) baby, there has been monumental progress in our field, including improvements in the techniques for stimulating ovarian follicles, retrieving oocytes, culturing fertilized eggs, and testing embryo biopsies. For example, the laparoscopic approach to oocyte retrieval, pioneered by gynecologist Patrick Steptoe, is now obsolete, and a transvaginal ultrasound-guided approach is the standard of care. Fertilization rates, especially in patients with severe male factor infertility, have increased with the innovation of intracytoplasmic sperm injection. The development of sequential culture media, coupled with changes in culture conditions, has increased both the blastocyst utilization and singleton live birth rates. In recognition of the significant impact made by the development of human IVF, British physiologist Robert Edwards received the Nobel prize in medicine in 2010.