Reply of the Authors: B-cell Lymphoma 6 (BCL6) Testing Before In Vitro Fertilization as a Predictor of Failure

Reply to Letter to the Editor

VOLUME 118, ISSUE 2, P420


Amber Klimczak, M.D., Richard T. Scott, M.D., H.C.L.D.


To the Editor: Previous studies have used B-cell lymphoma 6 (BCL6) testing during unstimulated ovulatory cycles to prognosticate endometrial receptivity during fresh in vitro fertilization (IVF) stimulation cycles (1). In our study, endometrial biopsy samples were collected from women undergoing ovulatory stimulation through assisted reproductive techniques during the midsecretory phase (8 days after trigger injection), which would be more similar to receptivity during a fresh embryo transfer cycle (2). We argue that performing a biopsy during an unstimulated ovulatory cycle and then using it to predict a fresh embryo transfer is illogical. To clarify, our biopsies were not performed during the frozen embryo transfer cycle as specified in point 2; therefore, concerns regarding its effects on implantation are mute. It is unlikely that an oocyte retrieval, which does not involve the uterus, would disrupt the endometrium and result in altered BCL6 expression. We did not use the ReceptivaDx test in this study.

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