Liver injury and ulipristal acetate: an overstated tragedy?


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Volume 110, Issue 4, Pages 593–595


Jacques Donnez, M.D., Ph.D.


Uterine fibroids are the most commonly encountered female pelvic tumors and the most frequent indication for hysterectomy (1) and associated with mortality rates of 0.02% to 0.17% and morbidity rates of 5.4% to 7.9%. Even myomectomy is not free of complications and the presence of myometrial scarring often requires caesarean section when giving birth.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. 


Go to the profile of Bruce Carr
over 3 years ago

Although the Author states that UPA is not a drug associated with Drug induced liver Disease (DILD) , there is strong evidence that this statement is not true.  For example another  progesterone receptor  modulator  onapristone and others were withdrawn from clinical trial because of serious effects on liver function (I.M. Spitz Contraception 82 (2010) 442-452.

In addition 

FDA Rejects Allergan's Uterine Fibroid Treatment Following EMA Concerns Over Liver Damage

 Published: Aug 22, 2018

Bruce R Carr MD



OCTOBER 19,2018