Views and Reviews

Introduction: Personalized medicine: what is it and what are the challenges?

Mark Sigman

Vol 109 | No. 6 | June 2018 | Pages 944–945

Using observational data for personalized medicine when clinical trial evidence is limited

Boris Gershman, David P. Guo, Issa J. Dahabreh

Vol 109 | No. 6 | June 2018 | Pages 946–951

Personalized medicine: motivation, challenges, and progress

Laura H. Goetz, Nicholas J. Schork

Vol 109 | No. 6 | June 2018 | Pages 952–963

Personalized reproductive medicine: regulatory considerations

Jonathan P. Jarow

Vol 109 | No. 6 | June 2018 | Pages 964–967

Personalized ovarian stimulation for assisted reproductive technology: study design considerations to move from hype to added value for patients

Ben W. Mol, Patrick M. Bossuyt, Sesh K. Sunkara, Juan A. Garcia Velasco, Christos Venetis, Denny Sakkas, Kersti Lundin, Carlos Simón, Hugh S. Taylor, Robert Wan, Salvatore Longobardi, Evelyn Cottell, Thomas D'Hooghe

Vol 109 | No. 6 | June 2018 | Pages 968–979

Fertile battle

A new clinical paradigm? Use of testicular sperm in the nonazoospermic male

Robert E. Brannigan

Vol 109 | No. 6 | June 2018 | Page 980

Use of testicular sperm in nonazoospermic males

Akanksha Mehta, Sandro C. Esteves, Peter N. Schlegel, Craig I. Niederberger, Mark Sigman, Armand Zini, Robert E. Brannigan

Vol 109 | No. 6 | June 2018 | Pages 981–987

Inklings

Scurvy and embryo culture

Kurt T. Barnhart

Vol 109 | No. 6 | June 2018 | Page 988

ASRM pages

Use of preimplantation genetic testing for monogenic defects (PGT-M) for adult-onset conditions: an Ethics Committee opinion

Ethics Committee of the American Society for Reproductive Medicine

Vol 109 | No. 6 | June 2018 | Pages 989–992

Comparison of pregnancy rates for poor responders using IVF with mild ovarian stimulation versus conventional IVF: a guideline

Practice Committee of the American Society for Reproductive Medicine

Vol 109 | No. 6 | June 2018 | Pages 993–999

Reflections

Dilemma of postvasectomy procreative management with older female partners: is in vitro fertilization really better?

Ajay K. Nangia

Vol 109 | No. 6 | June 2018 | Pages 1000–1001

Reduction in oxygen tension to 2% in extended culture: a more physiologic system may mean more blastocysts available for transfer

Scott J. Morin

Vol 109 | No. 6 | June 2018 | Pages 1002–1003

Cumulative pregnancy rates in women with poor ovarian response

James M. Goldfarb

Vol 109 | No. 6 | June 2018 | Pages 1004–1005

Alpha-fetoprotein in vaginal blood: a promising novel marker for early pregnancy failure that needs further validation

Beata E. Seeber

Vol 109 | No. 6 | June 2018 | Pages 1006–1007

Antimüllerian hormone and miscarriage: fifty shades of gray…

A. Musa Zamah, Mary D. Stephenson

Vol 109 | No. 6 | June 2018 | Pages 1008–1009

Role of adrenomedullin in reproduction and endometriosis

Mohamed Aboulghar

Vol 109 | No. 6 | June 2018 | Pages 1010–1011

Endometriosis: frightening the patients is not an acceptable alternative to inadequate surgical management and or pathophysiology ignorance

Michel Canis, Nicolas Bourdel, Pauline Chauvet

Vol 109 | No. 6 | June 2018 | Pages 1012–1013

Elective oocyte cryopreservation: an ounce of prevention?

Kara N. Goldman

Vol 109 | No. 6 | June 2018 | Pages 1014–1015

Contraception and reproductive health counseling in cancer survivorship—plan A rather than plan B

Leena Nahata, Gwendolyn P. Quinn

Vol 109 | No. 6 | June 2018 | Pages 1016–1017

I just can't do this anymore

Erica J. Mindes

Vol 109 | No. 6 | June 2018 | Pages 1018–1019

Original articles

Andrology

Reconsidering vasectomy reversal over assisted reproduction in older couples

Akash A. Kapadia, Marcus Anthony, Ann Martinez Acevedo, Eugene F. Fuchs, Jason C. Hedges, Kevin A. Ostrowski

Vol 109 | No. 6 | June 2018 | Pages 1020–1024

Assisted reproduction

Good-quality blastocysts derived from vacuolized morulas show reduced viability

Richard B. Mayer, Omar Shebl, Peter Oppelt, Elisabeth Reiter, Reinhard Altmann, S. Enengl, Christina Allerstorfer, Thomas Ebner

Vol 109 | No. 6 | June 2018 | Pages 1025–1029

Randomized controlled trial of low (5%) versus ultralow (2%) oxygen for extended culture using bipronucleate and tripronucleate human preimplantation embryos

Daniel J. Kaser, Berhan Bogale, Vishnudas Sarda, Leslie V. Farland, Paige L. Williams, Catherine Racowsky

Vol 109 | No. 6 | June 2018 | Pages 1030–1037.e2

Appraisal of clinical complications after 23,827 oocyte retrievals in a large assisted reproductive technology program

Paolo Emanuele Levi-Setti, Federico Cirillo, Valeria Scolaro, Emanuela Morenghi, Francesca Heilbron, Donatella Girardello, Elena Zannoni, Pasquale Patrizio

Vol 109 | No. 6 | June 2018 | Pages 1038–1043.e1

Elevated incidence of monozygotic twinning is associated with extended embryo culture, but not with zona pellucida manipulation or freeze-thaw procedure

Hanyan Liu, Jianqiao Liu, Shiping Chen, Xiangjin Kang, Hongzi Du, Lei Li

Vol 109 | No. 6 | June 2018 | Pages 1044–1050

Cumulative live birth rates in more than 3,000 patients with poor ovarian response: a 15-year survey of final in vitro fertilization outcome

Bei Xu, Yingjia Chen, Dirk Geerts, Jing Yue, Zhou Li, Guijin Zhu, Lei Jin

Vol 109 | No. 6 | June 2018 | Pages 1051–1059

Early pregnancy

Same-day confirmation of intrauterine pregnancy failure in women with first- and early second-trimester bleeding

Amir Mor, Reshef Tal, Shoshana Haberman, Bharati Kalgi, Susan Hosseini Nasab, Howard Minkoff

Vol 109 | No. 6 | June 2018 | Pages 1060–1064

Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies

Brianna M. Lyttle Schumacher, Anne Marie Z. Jukic, Anne Z. Steiner

Vol 109 | No. 6 | June 2018 | Pages 1065–1071.e1

Endometriosis

Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis

Brooke C. Matson, Kelsey E. Quinn, Bruce A. Lessey, Steven L. Young, Kathleen M. Caron

Vol 109 | No. 6 | June 2018 | Pages 1072–1078

Surgery for deep endometriosis without involvement of digestive or urinary tracts: do not worry the patients!

Aurélie Vallée, Stéphane Ploteau, Carole Abo, Emanuela Stochino-Loi, Salwa Moatassim-Drissa, Noémie Marty, Benjamin Merlot, Horace Roman

Vol 109 | No. 6 | June 2018 | Pages 1079–1085.e1

A stepped-care approach to symptomatic endometriosis management: a participatory research initiative

Paolo Vercellini, Agnese Donati, Federica Ottolini, Annalisa Frassineti, Jessica Fiorini, Vanessa Nebuloni, Maria Pina Frattaruolo, Anna Roberto, Paola Mosconi, Edgardo Somigliana

Vol 109 | No. 6 | June 2018 | Pages 1086–1096

Fertility preservation

To freeze or not to freeze: decision regret and satisfaction following elective oocyte cryopreservation

Eleni A. Greenwood, Lauri A. Pasch, Jordan Hastie, Marcelle I. Cedars, Heather G. Huddleston

Vol 109 | No. 6 | June 2018 | Pages 1097–1104.e1

Genetics

Mutational and functional studies on NR5A1 gene in 46,XY disorders of sex development: identification of six novel loss of function mutations

Maria Santa Rocca, Rita Ortolano, Soara Menabò, Federico Baronio, Alessandra Cassio, Gianni Russo, Antonio Balsamo, Alberto Ferlin, Lilia Baldazzi

Vol 109 | No. 6 | June 2018 | Pages 1105–1113

Gynecology

Use of emergency contraception among female young adult cancer survivors

Alexa C.O. Medica, Shaylyn S. Stark, Tracy N. Hadnott, Andrew C. Dietz, Sally A.D. Romero, Loki Natarajan, Elena Martinez, Brian W. Whitcomb, H. Irene Su

Vol 109 | No. 6 | June 2018 | Pages 1114–1120.e1

Mental health

Burden of care is the primary reason why insured women terminate in vitro fertilization treatment

Alice D. Domar, Kristin Rooney, Michele R. Hacker, Denny Sakkas, Laura E. Dodge

Vol 109 | No. 6 | June 2018 | Pages 1121–1126

Reproductive science

Karyotype of the blastocoel fluid demonstrates low concordance with both trophectoderm and inner cell mass

Olga Tšuiko, Daria I. Zhigalina, Tatjana Jatsenko, Nikolay A. Skryabin, Olga R. Kanbekova, Victoria G. Artyukhova, Anatoly V. Svetlakov, Katre Teearu, Aleksander Trošin, Andres Salumets, Ants Kurg, Igor N. Lebedev

Vol 109 | No. 6 | June 2018 | Pages 1127–1134.e1

Videos

Clinical use of endovenous indocyanine green during rectosigmoid segmental resection for endometriosis

Renato Seracchioli, Diego Raimondo, Alessandro Arena, Margherita Zanello, Mohamed Mabrouk

Vol 109 | No. 6 | June 2018 | Page 1135

Use of indocyanine green in endometriosis surgery

Yochay Bar-Shavit, Lucie Jaillet, Pauline Chauvet, Michel Canis, Nicolas Bourdel

Vol 109 | No. 6 | June 2018 | Pages 1136–1137