Organophosphate flame-retardant metabolite concentrations and pregnancy loss among women conceiving with assisted reproductive technology

Urinary concentrations of organophosphate flame-retardant metabolites measured in women undergoing ART increased the risk of early pregnancy loss.

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Volume 110, Issue 6, Pages 1137–1144.e1

Authors:

Carmen Messerlian, Ph.D., Paige L. Williams, Ph.D., Lidia Mínguez-Alarcón, Ph.D., Courtney C. Carignan, Ph.D., Jennifer B. Ford, B.N., Craig M. Butt, Ph.D., John D. Meeker, Ph.D., Heather M. Stapleton, Ph.D., Irene Souter, M.D., Russ Hauser, M.D., Sc.D. for the EARTH Study Team

Abstract:

Objective

To evaluate whether urinary concentrations of organophosphate flame retardant (PFR) metabolites are associated with pregnancy loss among women conceiving with assisted reproductive technology (ART).

Design

Prospective preconception cohort of subfertile women.

Setting

Academic hospital fertility center in Boston, Massachusetts.

Patient(s)

A total of 155 women conceiving 179 pregnancies with ART.

Intervention(s)

None. Mean exposure to each of five PFR metabolites was estimated by averaging the specific-gravity adjusted natural log concentrations from two urine samples collected during the ART cycle of conception.

Main Outcome Measure(s)

Adjusted risk ratios (RRs) and 95% confidence intervals (CIs) for biochemical and total pregnancy loss (all losses <20 weeks’ gestation) by quartiles of PFR metabolite concentrations were estimated using a repeated measures log-binomial model, accounting for multiple pregnancies per woman.

Result(s)

Of the 179 pregnancies, 31% ended in pregnancy loss (12% in biochemical loss). Among the three metabolites with high detection frequency [bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), diphenyl phosphate (DPHP), and isopropylphenyl phenyl phosphate (ip-PPP)], an increased risk of biochemical loss was observed for women with DPHP concentrations in the fourth vs. first quartile (RR 1.64; 95% CI 0.61–4.39). Also found was an elevated risk of biochemical pregnancy loss among women in the highest quartile of the molar sum of urinary PFR metabolites compared with the lowest (RR 1.89; 95% CI 0.64–5.58). Urinary concentrations of ip-PPP and BDCIPP were not associated with either outcome.

Conclusion(s)

Among subfertile women, urinary DPHP metabolite concentrations measured during the ART cycle of conception may be associated with early pregnancy loss. Although this study is uniquely designed to investigate early markers of pregnancy success and maintenance, the small sample size likely contributed to imprecision. Given their increasing use as replacement chemicals for traditional flame retardants, exposure to PFRs may increase, and more studies will be needed to investigate their potential to impact pregnancy and reproduction.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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