Dietary factors and serum antimüllerian hormone concentrations in late premenopausal women

In this cross-sectional analysis in a sample of late pre- menopausal women, findings suggest that dietary fat intake may be inversely associated with circulating AMH concentrations.

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Volume 110, Issue 6, Pages 1145–1153

Authors:

Chelsea Anderson, M.P.H., Yong-Moon Mark Park, Ph.D., Frank Z. Stanczyk, Ph.D., Dale P. Sandler, Ph.D., Hazel B. Nichols, Ph.D.

Abstract:

Objective

To study the associations between dietary factors and circulating antimüllerian hormone (AMH) concentrations among late premenopausal women.

Design

AMH concentrations were measured in serum samples collected at enrollment from 296 women (aged 35−45 years) in the Sister Study cohort. Usual dietary intakes in the past 12 months were assessed using a validated food frequency questionnaire. Dietary exposures of interest included macronutrients, dietary fat subtypes, fiber, and glycemic index. Multivariable linear regression was used to evaluate associations between dietary variables and serum AMH concentrations. We also used nutrient density models to examine isocaloric replacement of macronutrients.

Setting

Not applicable.

Patients

Women aged 35−45 years.

Interventions

Not applicable.

Main outcome measures

Serum AMH concentrations in nanograms per milliliter (ng/mL).

Results

AMH concentrations were positively associated with percentage of energy from carbohydrates (β per 5% calories = 0.141 [95% CI 0.023, 0.259]; P trend = .019), and inversely associated with percentage of energy from fat (β per 5% calories = −0.152 [95% CI −0.299, −0.004]; P trend = .044). In analyses of dietary fat subtypes, AMH decreased with increasing monounsaturated fatty acids (P trend = .082) and polyunsaturated fatty acids (Ptrend = .043), particularly ω-6 fatty acids (P trend = .044), whereas no strong trend was observed for saturated fatty acids. Protein and alcohol intake were not strongly associated with AMH.

Conclusions

Our cross-sectional analyses in a sample of late premenopausal women suggest that dietary fat intake may be inversely associated with circulating AMH concentrations. Further research in prospective studies is warranted to evaluate dietary factors as potential modifiers of ovarian reserve.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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