Oligo-anovulation is not a rarer feature in women with documented endometriosis

Oligo-anovulation is not an infrequent feature in women with documented endometriosis.

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Volume 110, Issue 5, Pages 941–948


Pietro Santulli, M.D., Ph.D., Chloe Tran, M.D., Vanessa Gayet, M.D., Mathilde Bourdon, M.D., Chloe Maignien, M.D., Louis Marcellin, M.D., Khaled Pocate-Cheriet, M.D., Charles Chapron, M.D., Dominique de Ziegler, M.D.



To study the prevalence of oligo-anovulation in women suffering from endometriosis compared to that of women without endometriosis.


A single-center, cross-sectional study.


University hospital-based research center.

Patient (s)

We included 354 women with histologically proven endometriosis and 474 women in whom endometriosis was surgically ruled out between 2004 and 2016.



Main Outcome Measure(s)

Frequency of oligo-anovulation in women with endometriosis as compared to that prevailing in the disease-free reference group.


There was no difference in the rate of oligo-anovulation between women with endometriosis (15.0%) and the reference group (11.2%). Regarding the endometriosis phenotype, oligo-anovulation was reported in 12 (18.2%) superficial peritoneal endometriosis, 12 (10.6%) ovarian endometrioma, and 29 (16.6%) deep infiltrating endometriosis.


Endometriosis should not be discounted in women presenting with oligo-anovulation.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.