Adiposity in polycystic ovary syndrome: excess versus dysfunction

Reflections
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Adiposity in polycystic ovary syndrome: excess versus dysfunction
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Adiposity in polycystic ovary syndrome: excess versus dysfunction

Adipose tissue is one of the most complex organs in the human body, involved in several critical processes, including whole-body energy regulation. Excess adiposity has often been considered integral to the disorder we know (at least for now) as polycystic ovary syndrome (PCOS). In 1935, Stein and L…

VOLUME 116, ISSUE 1, P87-88

Author:

Ricardo Azziz, M.D., M.P.H., M.B.A.

Abstract:

Reflections on "Accelerated subcutaneous abdominal stem cell adipogenesis predicts insulin sensitivity in normal-weight polycystic ovary syndrome women" by Dumesic et al.

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Go to the profile of Daniel
Daniel
over 1 year ago

We thank Dr. Azziz for his insightful comments and agree with his call for increased government funding for PCOS research, particularly with an emphasis on a multidisciplinary translational research approach. Equally important, women with PCOS are often dissatisfied with their healthcare (1-4), so that a revised healthcare strategy for PCOS women also is crucial to address their increased susceptibility to subfertility and metabolic disease in today’s obesogenic environment. An improved understanding of PCOS during obstetrics and gynecology residency as well as reproductive endocrinology and infertility fellowship should promote a greater knowledge of reproductive dysfunction, cardiometabolic comorbidities, mood-affective disorders and reduced quality of life; and should provide a better understanding of lifestyle modification and other beneficial interventions. Clinical exposure to complex reproductive-metabolic abnormalities with adverse implications to mother and offspring also is essential when caring for PCOS women who wish to conceive. Improved healthcare for PCOS women calls not only for government agencies to increase research funding, but also for academic medical institutions to improve education for this most common endocrine disorder of women.

Daniel Dumesic, M.D.

References

  1. Hoyos LR, Putra M, Armstrong AA, Cheng CY, Riesenberg C, Schooler TA, Dumesic D. Measures of patient dissatisfaction with health care in polycystic ovary syndrome: retrospective analysis. J Med Internet Res 2020;22(4):e16541.
  2. Dokras A, Saini S, Gibson-Helm M, Schulkin J, Cooney L, Teede H. Gaps in knowledge among physicians regarding diagnostic criteria and management of polycystic ovary syndrome. Fertil Steril. 2017 Jun;107(6):1380-1386.e1.
  3. Gibson-Helm M, Teede H, Dunaif A, Dokras A. Delayed Diagnosis and a Lack of Information Associated with Dissatisfaction in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2017 Feb 1;102(2):604-612.
  4. Cree-Green M. Worldwide Dissatisfaction with the Diagnostic Process and Initial Treatment of PCOS. J Clin Endocrinol Metab. 2017 Feb 1;102(2):375-378.

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