Fibroid stiffness: a cellular modulator of progesterone receptor signaling

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Fibroid stiffness: a cellular modulator of progesterone receptor signaling
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Fibroid stiffness: a cellular modulator of progesterone receptor signaling

Fibroids are characterized by the accumulation of extracellular matrix (ECM) and overexpression of collagens, giving these tumors their firm characteristics (1). This stiffness alters mechanotransduction, defined as a mechanism by which cells convert mechanical stimuli into biochemical signals. In a…

VOLUME 116, ISSUE 1, P91

Authors:

Omid Khorram, M.D., Ph.D., Tsai-Der Chuang, Ph.D.

Abstract:

Reflections on "Mechanical stiffness augments ligand-dependent progesterone receptor B activation via MEK 1/2 and Rho/ROCK-dependent signaling pathways in uterine fibroid cells" by Mitchell et al.

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