Vitamin D levels are not associated with ovarian reserve in a group of infertile women with a high prevalance of diminished ovarian reserve
Vitamin D levels are not associated with ovarian re- serve parameters in a large group of infertile women with a high prevalence of diminished ovarian reserve.
Volume 110, Issue 4, Pages 761–766.e1
Alice J. Shapiro, M.D., Sarah K. Darmon, Ph.D., David H. Barad, M.D., Norbert Gleicher, M.D., Vitaly A. Kushnir, M.D.
To determine whether a relationship exists between vitamin D (25OH-D) levels and ovarian reserve parameters (antimüllerian hormone [AMH] and FSH levels) in a large cohort of infertile women with a high prevalence of diminished ovarian reserve.
Retrospective cohort study.
Academically affiliated private fertility center.
A total of 457 infertile women 21–50 years of age who had baseline hormone measurements.
Main Outcome Measure(s)
Statistical analyses to determine whether a relationship exists between AMH, FSH, and serum 25OH-D levels.
As defined by 25OH-D <20.0 ng/mL, 74/457 patients (16.2%) had vitamin D deficiency. AMH and FSH levels did not vary between women with vitamin D deficiency and those with normal levels (0.8 ± 3.0 vs. 0.5 ± 1.6 ng/mL [P=.18] and 9.4 ± 7.2 vs. 9.2 ± 9.5 mIU/mL [P=.54], respectively). Multivariate linear regression analysis of log-transformed AMH and FSH with 25OH-D levels adjusted for age, body mass index, and seasonal variation confirmed lack of association. Receiver operating characteristic (ROC) analysis to determine if 25OH-D levels are predictive of AMH showed areas under the ROC curves (AUCs) for women <38 years of age to be 0.501, 0.554, and 0.511 for AMH threshold values of 0.5 ng/mL, 1.0 ng/mL, and 5.0 ng/mL, respectively. For women ≥38 years respective AUC values were 0.549, 0.545, and 0.557 ng/mL.
Vitamin D levels were not associated with ovarian reserve in a large group of infertile women with a high prevalence of diminished ovarian reserve. Previously reported vitamin D–associated outcomes in infertility patients may, therefore, be mediated by factors other than ovarian reserve.