Transplantation of cryopreserved ovarian tissue in a series of 285 women: a review of five leading European centers

Clinical experience of frozen-thawed ovarian tissue transplantation from 5 European centers confirms the validity of this new technique for fertility preservation.

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VOLUME 115, ISSUE 5, P1102-1115


Marie-Madeleine Dolmans, M.D., Ph.D, Michael von Wolff, M.D., Catherine Poirot, M.D., Ph.D., Cesar Diaz-Garcia, M.D., Ph.D., Luciana Cacciottola, M.D., Nicolas Boissel, M.D., Ph.D., Jana Liebenthron, Ph.D., Antonio Pellicer, M.D., Ph.D., Jacques Donnez, M.D., Ph.D., Claus Yding Andersen, MSc., D.MSc.


The feasibility of freezing and thawing ovarian tissue is nowadays widely documented. However, ovarian tissue transplantation (OTT) is happening at a much slower pace, and clinical experience is somewhat limited. In this review, five European centers present their collective experience of transplanting ovarian tissue in 285 women. The focus is on surgical techniques and OTT outcomes, reproductive outcomes, the impact of chemotherapy before ovarian tissue cryopreservation (OTC), the risk of relapse, and endocrine resumption and longevity of transplanted tissue.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.