Endometritis: new time, new concepts

In this review article, we aimed to renew the knowledge on the epidemiology, etiology, and pathogenesis of chronic endometritis and discuss its clinical diagnosis and management in infertility treatment.

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Volume 110, Issue 3, Pages 344–350


Kotaro Kitaya, M.D., Takumi Takeuchi, M.D., Shimpei Mizuta, M.Sc., Hidehiko Matsubayashi, M.D., Tomomoto Ishikawa, M.D.


Endometritis is subdivided into two categories. Acute endometritis is symptomatic and characterized by microabscess formation and neutrophil invasion in the endometrial superficial epithelium, gland lumina, and uterine cavity. Chronic endometritis is rather silent and recognized as unusual plasmacyte infiltration in the endometrial stromal areas. Over the last decade, studies have disclosed the potential association between poor reproductive outcomes and endometritis, particularly chronic endometritis. The aim of this review is to address the current literature surrounding chronic endometritis and highlight recent advances in the research of this long-neglected gynecologic disease.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.