Use of preimplantation genetic testing for monogenic defects (PGT-M) for adult-onset conditions: an Ethics Committee opinion

This document discusses the ethical considerations of performing preimplantation genetic testing for monogenic disease to deselect embryos for transfer in order to prevent future adult-onset conditions in the offspring.

Volume 109, Issue 6, Pages 989–992


Ethics Committee of the American Society for Reproductive Medicine


Preimplantation genetic testing for monogenic diseases for adult-onset conditions is ethically permissible for a range of conditions including when the condition is serious and no safe, effective interventions are available. The Committee strongly recommends that a genetic counselor experienced with PGT-M counsel patients considering such procedures. This document replaces the document titled “Use of preimplantation genetic diagnosis for serious adult-onset conditions: a committee opinion,” last published in Fertil Steril 2013;100;54-7.

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