Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis

Persistent endometrial inflammation, as encountered in case of endometriosis and chronic endometritis, causes endometrial alterations leading to improper placentation and increased risk of miscarriage and recurrent pregnancy loss.

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VOLUME 115, ISSUE 3, P546-560, MARCH 01, 2021


Paul Pirtea, M.D., Ettore Cicinelli, M.D., Ph.D., Rosalba De Nola, M.D., Dominique de Ziegler, M.D., Jean Marc Ayoubi, M.D., Ph.D.


Chronic inflammatory processes affecting the endometrium, as encountered in endometriosis, adenomyosis, and chronic endometritis, alter endometrial receptivity. These disorders are associated with early pregnancy losses and possibly recurrent pregnancy losses (RPL). In the cases of endometriosis, other factors associated with the disease also are susceptible of causing miscarriages and possibly RPL, such as an impact of intrapelvic inflammatory processes affecting the oocyte and embryo in case of natural conception. Conversely these latter effects obviously are bypassed in case of assisted reproductive technology. Chronic inflammation of the endometrium in the condition known as chronic endometritis also causes early pregnancy losses and RPL with beneficial effects achieved when specific treatment is undertaken.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.