What should the first-line treatment for couples with unexplained infertility be: intrauterine insemination or in vitro fertilization?

Fertile Battle

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VOLUME 114, ISSUE 6, P1140


Cynthia Farquhar, M.B.Ch.B., M.D., M.P.H.


This Fertile Battle considers the debate about the optimal approaches for unexplained infertility. Couples with unexplained infertility, according to the International Committee for Monitoring Assisted Reproductive Technologies definition, have “apparently normal ovarian function, normal fallopian tubes, uterus, cervix and pelvis, adequate coital frequency, apparently normal testicular function, genitourinary anatomy and a normal ejaculate” (1). Estimates for the proportion of couples with unexplained infertility range from 15% to 30% and will increase with increasing age.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.