Impact of the levonorgestrel-releasing intrauterine device on controlled ovarian stimulation outcomes

Levonorgestrel-releasing intrauterine devices do not affect oocyte yield in controlled ovarian stimulation cycles.

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Volume 110, Issue 1, Pages 83–88


Amanda J. Adeleye, M.D., Lusine Aghajanova, M.D., Ph.D., Chia-Ning Kao, M.S., Marcelle I. Cedars, M.D., Mark V. Sauer, M.D.



To report differences in ovarian stimulation outcomes in women using a levonorgestrel-releasing intrauterine device (LNG-IUD).


Retrospective cohort study.


University-based infertility practice.


Female patients pursuing either social oocyte cryopreservation or oocyte donation.


Chart review of all female patients presenting from January 1, 2012, to June 30, 2017, for social oocyte cryopreservation or oocyte donation. Demographic data, cycle performance data, and the presence or absence of an LNG-IUD at the time of ovarian stimulation were compared.

Main Outcome Measure(s)

Total oocyte yield and total mature oocyte yield. Secondary measures included clinical pregnancy rate and live birth rate in recipients of donor oocytes.


Univariate analysis of predicted oocyte yield and mature oocyte yield showed no significant difference between subjects with and without an LNG. When controlling for history of recent hormonal contraceptive use, initial antral follicle count (AFC), age, body mass index (BMI), gonadotropin dose, and stimulation day/protocol, no significant differences were seen in total oocyte yield or mature oocyte yield in the presence or absence of an LNG-IUD. Univariate analysis of the effect of LNG-IUDs on the predicted clinical pregnancy rate and live birth rate did not significantly differ for oocyte recipients. Controlling for history of recent hormonal contraceptive use, initial AFC, age, BMI, gonadotropin dose, and stimulation day/protocol also showed no significant differences in the predicted clinical pregnancy rate and live birth rate.


LNG-IUDs do not affect cycle performance in women undergoing ovarian stimulation cycles.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.


Go to the profile of Francisca Martinez
over 2 years ago

Dear Dr Adeleye, I was surprised by the astonishing  high clinical and live birth  reported in your paper. I am curious about the endometrial preparation used ,  the number of blastocyst transferred and the multiple pregnancy rate.  Thank you very much for your attention