Utility of gonadotropin-releasing hormone agonists for fertility preservation in women receiving chemotherapy: pros and cons

Fertile Battle

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VOLUME 114, ISSUE 4, P725-738


Marie-Madeleine Dolmans, M.D., Ph.D., Hugh S. Taylor, M.D., Kenny A. Rodriguez-Wallberg, M.D., Ph.D., Zeev Blumenfeld, M.D., Matteo Lambertini, M.D., Ph.D., Michael von Wolff, M.D., Jacques Donnez, M.D., Ph.D.


Con: GnRH-a should not be used for fertility preservation in women receiving chemotherapy

Pro: PRO: GnRH-a should be used for fertility preservation in women receiving chemotherapy

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Should GnRH-a be used for fertility preservation in women receiving chemotherapy?
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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. 


Go to the profile of Pandiyan  Natarajan
24 days ago

GnRH helps in Fertility preservation.

The chemotherapeutic drugs are mostly toxic to all cells. However, they are far more toxic  to rapidly dividing cells as in the bone marrow, gastro intestinal tract, bone marrow, gonads and hair, than other less rapidly dividing cells. We hypothesized in an article in RBMO in the inaugural issue of the Journal, that GnRH, by gonadal suppression, will reduce the risk of chemotherapy. (1)

The peer reviewers had reservation about this suggestion. However, 20 years later, we find our suggestion seems to work in a large number of people.

1) Pandiyan N. Medical management of male infertility. Reprod Biomed Online. 2000;1(1):13-6. doi: 10.1016/s1472-6483(10)61987-6. PMID: 12804206.

Professor Dr Pandiyan Natarajan,

Apollo 24/7.

Chief Consultant in Andrology and Reproductive Medicine and
Head of the Department of Reproductive Medicine, ( Retired )
Chettinad Super Speciality Hospital,

Chief Editor,  Chettinad Health City Medical Journal,
Director, International Academic Affiliations,
Chettinad Academy of Research & Education, ( Retired )