Routine endometrial receptivity array in first embryo transfer cycles does not improve live birth rate

Routine endometrial receptivity array in an unselected infertile population prior to first single euploid programmed frozen embryo transfer does not improve live birth rate.

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VOLUME 115, ISSUE 4, P1001-1006

Authors:

Carrie Riestenberg, M.D., Lindsay Kroener, M.D., Molly Quinn, M.D., Kaycee Ching, B.S., Gayane Ambartsumyan, M.D., Ph.D.

Abstract:

Objective

To compare the live birth rate between patients who undergo personalized embryo transfer (pET) after endometrial receptivity array (ERA) versus frozen embryo transfer (FET) with standard timing in first single euploid FET cycles. To report the rate of displacement of the window of implantation (WOI) in an infertile population without a history of implantation failure.


Design

Prospective cohort study of patients who underwent their first single euploid programmed FET.


Setting

Private fertility clinic.


Patient(s)

Patients who underwent first autologous single euploid programmed FET between January 2018 and April 2019.


Intervention(s)

Endometrial biopsy with ERA followed by pET as indicated.


Main Outcome Measure(s)

Live birth rate and rate of receptive and nonreceptive ERA.


Result(s)

A total of 228 single euploid FET cycles were included in our analysis. Of those, 147 (64.5%) were ERA/pET cycles, and 81 (35.5%) were standard timing FET cycles. Endometrial receptivity array was receptive in 60/147 (40.8%) and nonreceptive in 87/147 (59.2%) patients. Nonreceptive ERAs were prereceptive in 93.1% of cases. The live birth rate did not differ between patients who underwent FET with standard timing and patients who underwent ERA/pET, 45/81 (56.6%) and 83/147 (56.5%), respectively.


Conclusion(s)

Our data do not support the routine use of ERA in an unselected patient population undergoing first autologous single euploid programmed embryo transfer.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. 

Comments

Go to the profile of Yang
about 2 months ago

Is this a "Prospective cohort study" as the author mentioned in the "Design" part? Why the number of cases differs from the post (P430) on 2020 ASRM?