Intracytoplasmic sperm injection (ICSI) for non–male factor indications: a committee opinion

This committee opinion assesses the literature, where available, to identify situations where intracytoplasmic sperm injection may be appropriate for non–male factor indications.

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VOLUME 114, ISSUE 2, P239-245


Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology


Intracytoplasmic sperm injection, while typically effective for overcoming low or absent fertilization in couples with a clear abnormality of semen parameters, is frequently used in combination with assisted reproductive technologies for other etiologies of infertility in the presence of semen parameters that meet the World Health Organization 2010 normative reference values. This committee opinion provides a critical review of the literature, where available, to identify situations where this may or may not be of benefit. This document replaces the previously published document of the same name, last published in 2012 (Fertil Steril 2012;98:1395–9).

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.