Abnormal activation of the sonic hedgehog signaling pathway in endometriosis and its diagnostic potency

The expression of sonic hedgehog pathway molecules is increased in the eutopic endometria of patients with endometriosis compared to control patients, and can predict the onset and severity of the disease.

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Authors:

Yanan He, Ph.D., Qiuyan Guo, Ph.D., Yan Cheng, Ph.D., Yanjun Qu, Ph.D., Liyuan Sun, M.D., Congcong Kong, M.D., Liang Lei, M.D., Guangmei Zhang, Ph.D.

Abstract:

Objective

To investigate the abnormal expression of sonic hedgehog (SHH) signaling molecules in 52 eutopic endometrial tissues and its diagnostic potency in endometriosis.

Design

Retrospective study.

Setting

University hospital.

Patient(s)

Twenty-six women with histologically confirmed endometriosis and 26 women with histologically normal endometria who were undergoing curettage or hysterectomy were selected.

Intervention(s)

None.

Main Outcome Measure(s)

The mRNA and protein levels of molecules in the SHH signaling pathway.

Result(s)

The levels of SHH, smoothened, GLI family zinc finger 3, and its downstream signaling transcription factor (GLI1) not only were upregulated in the eutopic endometrium of endometriosis compared with the control endometrium, but also independently predicted the onset and severity of the disease.

Conclusion(s)

This study is the first to reveal differences in the activation of the SHH signaling pathway between women with and without endometriosis and suggests that the SHH signaling pathway has potential in the diagnosis of endometriosis.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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