Time-lapse imaging: clearly useful to both laboratory personnel and patient outcomes versus just because we can doesn't mean we should

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Volume 109, Issue 4, Pages 584–591


Richard J. Paulson, M.D., M.S., David E. Reichman, M.D., Nikica Zaninovic, M.S., Ph.D., H.C.L.D., E.L.D., Linnea R. Goodman, M.D., Catherine Racowsky, Ph.D.


Over the last 50 years, embryo culture techniques for in vitro fertilization (IVF) have continued to evolve. The latest evolution raises a controversial question—whether culturing embryos in systems which allow for undisturbed time-lapse monitoring (TLM) improve our fundamental understanding of embryogenesis, and whether that understanding can reliably translate into improved clinical outcomes (1).

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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.


Go to the profile of Micah J Hill
Micah J Hill almost 3 years ago

Thank you for this fantastic review of time-lapse imaging.  Amazingly balanced, critical, insightful and succinct!    I know we need more data, but what is the authors gut feeling on the future of time-lapse imaging?  Mainstream and here to stay or another modality that falls to the curb?

Go to the profile of Richard J. Paulson
Richard J. Paulson almost 3 years ago

Thanks, Micah! It definitely adds information. Whether a lab adds that information may depend on whether it costs $1,000, $10,000 or $100,000.