The use of preimplantation genetic testing for aneuploidy (PGT-A): a committee opinion

Use of preimplantation genetic testing for aneuploidy (PGT-A) in select patients undergoing in vitro fertilization has been theorized to allow for higher live-birth rates when increased elective single-embryo transfer is used. PGT-A testing reliability has recently come under scrutiny. The impact of mosaicism on testing re- liability and embryo damage from the biopsy still need to be determined.

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Fertility and Sterility
Editorial Office, American Society for Reproductive Medicine
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Volume 109, Issue 3, Pages 429–436

Authors:

Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology 

Abstract:

The value of preimplantation genetic testing for aneuploidy (PGT-A) as a screening test for in vitro fertilization (IVF) patients has yet to be determined. Several studies demonstrate higher birth rates after aneuploidy testing and elective single-embryo transfer (eSET), suggesting the potential for this testing to decrease the risk of multiple gestations, though these studies have important limitations.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.