Cancer biomarkers and fertility
We discuss the significant data linking infertility as a possible biomarker for cancer in infertile men and the burgeoning data linking them in infertile women.
Volume 109, Issue 1, Pages 4–5
James M. Hotaling, M.D., M.S., Neri Laufer, M.D., Zev Rosenwaks, M.D.
Infertility has been increasingly recognized as a possible biomarker for cancer risk. There is significant data linking these two seemingly disparate diseases in infertile men and burgeoning data linking them in infertile women. Here we investigate the possible mechanisms whereby one shared genetic or epigenetic insult could confer increased risk for both infertility and cancer.