Volume 109, Issue 1, Pages 4–5
James M. Hotaling, M.D., M.S., Neri Laufer, M.D., Zev Rosenwaks, M.D.
Infertility has been increasingly recognized as a possible biomarker for cancer risk. There is significant data linking these two seemingly disparate diseases in infertile men and burgeoning data linking them in infertile women. Here we investigate the possible mechanisms whereby one shared genetic or epigenetic insult could confer increased risk for both infertility and cancer.