Successful quintuplet pregnancy of monochorionic male quadruplets and single female after double embryo transfer: case report and review of the literature

A 37-year-old G1P1 having two embryos transferred delivered quintuplets of monochorionic male quadruplets and a single female with successful outcome. Monozygotic twinning is a risk in assisted reproductive pregnancies.

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Volume 109, Issue 2, Pages 284–288


Ryan Schlueter, D.O., Christina Arnett, M.D., Christopher Huang, M.D., Janet Burlingame, M.D.



To report a rare case of quintuplets with monochorionic male quadruplets and a single female after two-blastocyst transfer.


Case report.


University teaching hospital.


A 37-year-old gravida 1, para 1, presenting after two-embryo IVF with monochorionic male quadruplets and a single female.


Ultrasound examinations and cesarean delivery.

Main Outcome Measure(s)

Successful delivery of five live-born infants at 28 weeks and 6 days of gestation for preterm labor.


The patient was diagnosed with quintuplets consisting of monochorionic male quadruplets and a single female after the placement of two embryos in blastocyst stage. She was followed closely with ultrasound examinations and hospitalized at 23 weeks’ gestation. Cesarean delivery was performed at 28 weeks and 6 days of gestation, with eventual discharge of all infants in healthy condition.


This case represents successful assisted reproductive technology quintuplets with monochorionic quadruplets and a co-sibling. Higher-order monozygotic pregnancies with monochorionic quadruplets are exceedingly rare and a potential complication of IVF.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.