Endometrial scratching to increase pregnancy rates with intrauterine insemination

Reflections

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Volume 109, Issue 1, Page 56

Authors:

Jeffrey M. Goldberg, M.D.

Abstract:

Reflections on "Endometrial scratch injury before intrauterine insemination: is it time to re-evaluate its value? Evidence from a systematic review and meta-analysis of randomized controlled trials" by Vitagliano et al.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

1 Comments

Go to the profile of Deepa Bhartiya
Deepa Bhartiya over 2 years ago

Dear Prof Goldberg.  Very nice compilation of the field.  Besides facilitating decidualization or activation of immune response or helping to improve synchrony - endometrial scratching may also lead to increased mobilization of stem cells to the site of injury where they undergo differentiation and improve endometrial cells population comprising the receptive site.  Stem cells are known to get mobilized in response to stress in an attempt to restore homeostasis.  However, this needs to be demonstrated in animal models.  Is there any mouse model to study this?