Does cumulative live birth plateau beyond a certain ovarian response?
Volume 108, Issue 6, Page 943
Ernesto Bosch, M.D., Elena Labarta, M.D., Antonio Pellicer, M.D.
Currently, patients undergoing in vitro fertilization (IVF) demand the process be optimized so their goal is achieved after a single cycle. The outcome of the ovarian stimulation procedure, from the perspectives of efficacy and safety, is crucial to reach this goal through the harvest of an optimal number of oocytes while avoiding such complications as ovarian hyperstimulation syndrome (OHSS). An interesting debate on whether the live-birth rate (LBR) plateaus beyond a certain number of oocytes retrieved is currently ongoing. While there is a general agreement regarding this event when only the fresh embryo transfer is considered, much more controversy has been generated recently when the cumulative outcome (i.e., including pregnancies achieved with the transfer of super numerous frozen embryos) is discussed.