Effect of the initiation of progesterone supplementation in in vitro fertilization–embryo transfer outcomes: a prospective randomized controlled trial

We discuss the influence of the start point of luteal sup- port on clinical pregnancy rate, implantation rate, and live birth rate of in vitro fertilization and embryo transfer cycles.
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Volume 109, Issue 1, Pages 97–103

Authors:

Jun Gao, Ph.D., Fang Gu, M.D., Ben-Yu Miao, Ph.D., Ming-Hui Chen, Ph.D., Can-Quan Zhou, M.D., Yan-Wen Xu, Ph.D.

Abstract:

Objective

To analyze the influence of the start point of luteal support on clinical pregnancy rate, implantation rate, and live birth rate of in vitro fertilization and embryo transfer (IVF-ET) cycles.

Design

Single-center prospective randomized controlled trial.

Setting

University-affiliated IVF unit.

Patient(s)

Women ≤35 years of age with day 3 FSH levels <15 mIU/mL, who were undergoing their first IVF-ET cycles and received ovarian stimulation with the use of a GnRH agonist long protocol.

Intervention(s)

The patients were randomized on the day of hCG trigger to receive luteal phase support either 1 day after oocyte retrieval (group A) or on the day of oocyte retrieval (group B).

Main Outcome Measure(s)

Clinical pregnancy rate, implantation rate, miscarriage rate in the first trimester of pregnancy, and live birth rate per embryo transfer cycle.

Result(s)

Two hundred thirty-three patients were enrolled in this study: 117 were assigned to group A and 116 to group B. The clinical pregnancy rate (group A vs. group B: 55.3% vs. 51.5%), implantation rate (38.4% vs. 38.0%), and miscarriage rate (7.7% vs. 7.5%) were similar between the two groups. The live birth rate also did not significantly differ between the two groups (45.7% vs. 46.6%).

Conclusion(s)

Our study indicated that the initiation of progesterone supplementation 1 day after oocyte retrieval did not decrease the clinical pregnancy rate, implantation rate, or live birth rate in women undergoing IVF-ET cycles with the use of the GnRH agonist long protocol.

Clinical Trial Registration Number

ChiCTR-IPR-14005293.


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