Quality of life, psychosocial and physical wellbeing among 1023 women during their first ART treatment: Secondary outcome to a RCT comparing GnRH-antagonist and GnRH-agonist protocol
Women in gonadotropin-releasing hormone (GnRH)- antagonist protocol rated psychosocial and physical well-being during first assisted reproductive technology treatment better than did women in GnRH-agonist protocol. However, the one item on self-reported quality of life was rated similarly.
Volume 109, Issue 1, Pages 154–164
Mette Toftager, M.D., Ph.D., Randi Sylvest, M.Sc., Lone Schmidt, M.D., Ph.D., D.M.Sc., Jeanette Bogstad, M.D., Kristine Løssl, M.D., Ph.D., Lisbeth Prætorius, M.D., Anne Zedeler, Ph.D., Thue Bryndorf, M.D., D.M.Sc., Anja Pinborg, M.D., D.M.Sc.
To compare self-reported quality of life, psychosocial well-being, and physical well-being during assisted reproductive technology (ART) treatment in 1,023 women allocated to either a short GnRH antagonist or long GnRH agonist protocol.
Secondary outcome of a prospective phase 4, open-label, randomized controlled trial. Four times during treatment a questionnaire on self-reported physical well-being was completed. Further, a questionnaire on self-reported quality of life and psychosocial well-being was completed at the day of hCG testing.
Fertility clinics at university hospitals.
Women referred for their first ART treatment were randomized in a 1:1 ratio and started standardized ART protocols.
Gonadotropin-releasing hormone analogue; 528 women allocated to a short GnRH antagonist protocol and 495 women allocated to a long GnRH agonist protocol.
Main Outcome Measure(s)
Self-reported quality of life, psychosocial well-being, and physical well-being based on questionnaires developed for women receiving ART treatment.
Baseline characteristics were similar, and response rates were 79.4% and 74.3% in the GnRH antagonist and GnRH agonist groups, respectively. Self-reported quality of life during ART treatment was rated similar and slightly below normal in both groups. However, women in the GnRH antagonist group felt less emotional (adjusted odds ratio [AOR] 0.69), less limited in their everyday life (AOR 0.74), experienced less unexpected crying (AOR 0.71), and rated quality of sleep better (AOR 1.55). Further, women receiving GnRH agonist treatment felt worse physically.
Women in a short GnRH antagonist protocol rated psychosocial and physical well-being during first ART treatment better than did women in a long GnRH agonist protocol. However, the one item on self-reported general quality of life was rated similarly.