Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis

Metabolic syndrome, hypertension, and dyslipidemia cluster in first-degree relatives of women with polycystic ovary syndrome.

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Volume 109, Issue 2, Pages 356–364.e32


Bulent Yilmaz, M.D., Priyathama Vellanki, M.D., Baris Ata, M.D., M.Sc., Bulent Okan Yildiz, M.D.



To provide an evidence-based assessment of metabolic syndrome, hypertension, and hyperlipidemia in first-degree relatives of women with polycystic ovary syndrome (PCOS).


Systematic review and meta-analysis.


Not applicable.


Mothers, fathers, sisters, and brothers of women with and without PCOS.


An electronic-based search with the use of PubMed from 1960 to June 2015 and cross-checked references of relevant articles.

Main Outcome Measure(s)

Metabolic syndrome, hypertension and dyslipidemia, and surrogate markers, including systolic blood pressure (BP), diastolic BP, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides.


Fourteen of 3,346 studies were included in the meta-analysis. Prevalence of the following was significantly increased in relatives of women with PCOS: metabolic syndrome (risk ratio [RR] 1.78 [95% confidence interval 1.37, 2.30] in mothers, 1.43 [1.12, 1.81] in fathers, and 1.50 [1.12, 2.00] in sisters), hypertension (RR 1.93 [1.58, 2.35] in fathers, 2.92 [1.92, 4.45] in sisters), and dyslipidemia (RR 3.86 [2.54, 5.85] in brothers and 1.29 [1.11, 1.50] in fathers). Moreover, systolic BP (mothers, sisters, and brothers), total cholesterol (mothers and sisters), low-density lipoprotein cholesterol (sisters), and triglycerides (mothers and sisters) were significantly higher in first-degree relatives of PCOS probands than in controls.


Our results show evidence of clustering for metabolic syndrome, hypertension, and dyslipidemia in mothers, fathers, sisters, and brothers of women with PCOS.

Systematic Review Registration Number

PROSPERO 2016 CRD42016048557.

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Fertility and Sterility

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