Admixture mapping of uterine fibroid size and number in African American women

Global ancestry analyses revealed that increasing African ancestry proportion is associated with risk of developing multiple fibroids. Admixture mapping analyses identified novel genomic regions associated with fibroid number and volume.

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Volume 108, Issue 6, Pages 1034–1042.e26

Authors:

Michael J. Bray, B.S., Todd L. Edwards, Ph.D., Melissa F. Wellons, M.D., Sarah H. Jones, B.A., Katherine E. Hartmann, M.D., Ph.D., Digna R. Velez Edwards, Ph.D.

Abstract:

Objective

To evaluate the relationship between genetic ancestry and uterine fibroid characteristics.

Design

Cross-sectional study.

Setting

Not applicable.

Patient(s)

A total of 609 African American participants with image- or surgery-confirmed fibroids in a biorepository at Vanderbilt University electronic health record biorepository and the Coronary Artery Risk Development in Young Adults studies were included.

Intervention(s)

None.

Main Outcome Measure(s)

Outcome measures include fibroid number (single vs. multiple), volume of largest fibroid, and largest fibroid dimension of all fibroid measurements.

Result(s)

Global ancestry meta-analyses revealed a significant inverse association between percentage of European ancestry and risk of multiple fibroids (odds ratio: 0.78; 95% confidence interval 0.66, 0.93; P=6.05 × 10−3). Local ancestry meta-analyses revealed five suggestive (P<4.80 × 10−3) admixture mapping peaks in 2q14.3-2q21.1, 3p14.2-3p14.1, 7q32.2-7q33, 10q21.1, 14q24.2-14q24.3, for number of fibroids and one suggestive admixture mapping peak (P<1.97 × 10−3) in 10q24.1-10q24.32 for volume of largest fibroid. Single variant association meta-analyses of the strongest associated region from admixture mapping of fibroid number (10q21.1) revealed a strong association at single nucleotide polymorphism variant rs12219990 (odds ratio: 0.41; 95% confidence interval 0.28, 0.60; P=3.82 × 10−6) that was significant after correction for multiple testing.

Conclusion(s)

Increasing African ancestry is associated with multiple fibroids but not with fibroid size. Local ancestry analyses identified several novel genomic regions not previously associated with fibroid number and increasing volume. Future studies are needed to explore the genetic impact that ancestry plays into the development of fibroid characteristics.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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