Association between ABO blood type and live-birth outcomes in single-embryo transfer cycles

ABO blood type is not associated with live-birth rate, birth weight, or gestational age at delivery in patients undergoing single day 5 embryo transfer.

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Volume 108, Issue 5, Pages 791–797

Authors:

Nigel Pereira, M.D., Hency H. Patel, B.S., Logan D. Stone, B.A., Paul J. Christos, Dr.P.H., M.S., Rony T. Elias, M.D., Steven D. Spandorfer, M.D., Zev Rosenwaks, M.D.

Abstract:

Objective

To investigate the association between ABO blood type and live-birth outcomes in patients undergoing IVF with day 5 single embryo transfer (SET).

Design

Retrospective cohort study.

Setting

University-affiliated center.

Patient(s)

Normal responders, <40 years old, undergoing their first IVF cycle with fresh SET.

Intervention(s)

None.

Main Outcome Measure(s)

Live-birth rate was the primary outcome. Secondary outcomes were birth weight and gestational age at delivery. Univariate and multivariable logistic regression was used to examine the association between blood type and live birth, while controlling for confounders. Odds ratios (OR) with 95% confidence intervals (CI) for live birth were estimated.

Result(s)

A total of 2,329 patients were included. The mean age of the study cohort was 34.6 ± 4.78 years. The distribution of blood types was as follows: A = 897 (38.5%); B = 397 (17.0%); AB = 120 (5.2%); and, O = 1,915 (39.3%) patients. There was no difference in the baseline demographics, ovarian stimulation, or embryo quality parameters between the blood types. The unadjusted ORs for live birth when comparing blood type A (referent) with blood types B, AB, and O were 0.96 (95% CI, 0.6–1.7), 0.72 (95% CI, 0.4–1.2), and 0.96 (95% CI. 0.6–1.7), respectively. The adjusted ORs for live birth remained not significant when comparing blood type A to blood types B, AB, and O individually. No difference in birth weight or gestational age at delivery was noted among the four blood types.

Conclusion(s)

Our findings suggest that ABO blood type is not associated with live-birth rate, birth weight, or gestational age at delivery in patients undergoing IVF with day 5 SET.


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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