Patient-tailored ovarian stimulation for in vitro fertilization
The background and preliminary studies regarding individualized dosing for ovarian stimulation in in vitro fertilization are discussed.
Volume 108, Issue 4, Pages 585–591
Bart C.J.M. Fauser, M.D., Ph.D.
At present, much attention in medicine is being directed toward individualized or patient-tailored care with the use of novel tools such as biomarkers or genomics. Research tools different from randomized controlled trials, focusing on the heterogeneity of patients rather than the intervention per se, are required to develop this concept further. In infertility care, few examples of individualized approaches with the use of multivariate prediction models can be found, such as the prediction of spontaneous conception chances in infertile patients or regarding the medical treatment of anovulatory infertility. Few prospective studies have been published in recent years concerning individualized dosing based on response prediction for ovarian stimulation in IVF. Potentially much may be gained by such methods because at present ovarian response to stimulation varies greatly, with distinct implications for both efficacy and safety of IVF treatment.