Clinical validation of pinopode as a marker of endometrial receptivity: a randomized controlled trial

Pinopode scoring proves to be a reliable marker for endometrial receptivity, and individual embryo transfer based on pinopode scoring is a promising solution for recurrent implantation failure.

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Volume 108, Issue 3, Pages 513–517.e2

Authors:

Zhang Qiong, M.D., Hao Jie, M.D., Wang Yonggang, M.D., Xu Bin, M.D., Zhao Jing, M.D., Li Yanping, Ph.D.

Abstract:

Objective

To determine the clinical value of pinopodes in the human.

Design

Randomized controlled trial.

Setting

Academic fertility center.

Patient(s)

From December 2014 to December 2016, in a phase I trial, 363 patients were recruited in their first IVF cycles. In a phase II trial, 136 patients with at least two previous embryo implantation failures were recruited.

Intervention(s)

In the phase I trial, in the midluteal phase, endometrial tissues were obtained for scanning electron microscopy, and their IVF treatment outcomes were followed up. In the phase II trial, participants were allocated into two groups by random number table, and the experimental group had twice the number of the control group. Individual ETs (iETs) were performed in the experimental group, while frozen-thawed embryos were routinely transferred in the control group.

Main Outcome Measure(s)

Clinical pregnancy rate (CPR) and ongoing pregnancy rate (OPR).

Result(s)

In the phase I trial, through receiver operation characteristic curve analysis, the optimal pinopode scoring for successful clinical pregnancy was determined to be 85. The CPR (74.29% vs. 19.77%) and OPR (62.86% vs 11.86%) were significantly higher in the patients whose pinopode scoring was >85. In the phase II trial, the CPR was dramatically higher in the iET group (33.82% vs. 8.11%).

Conclusion(s)

Pinopode scoring is a reliable marker of endometrial receptivity, and iET based on pinopode scoring is a promising solution for recurrent implantation failure.

Trial Registration Numbers

ChiCTR-OOC-14005617; ChiCTR-OOC-15005882.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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