Recurrent implantation failure is a pathology with a specific transcriptomic signature

Recurrent implantation failure can be predicted by means of a specific endometrial transcrip- tomic signature.

Like Comment

Volume 108, Issue 1, Pages 9–14


Nick Macklon, M.D., Ph.D.


Recurrent implantation failure (RIF) is a source of distress and frustration to both patients and their clinicians. In the absence of clinically useful tests, the therapeutic approach has been largely empirical, with limited efficacy. In recent years, new insights into the role of the endometrium in implantation have emerged, and a number of dysfunctions that may underlie implantation failure have been characterized. These point to the presence, in some patients, of an underlying endometrial pathology. In this article, the case is made that constitutive (rather than maturation) defects underlying RIF can be identified. Evidence is presented of a specific transcriptomic signature that is highly predictive of RIF.

Read the full text here.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.