Endometrial microbiota—new player in town

The characterization of an indigenous uterine micro- biota through next-generation sequencing opens new opportunities for the assessment of endometrial microbial health and its influence on reproduc- tive success.
Endometrial microbiota—new player in town

Volume 108, Issue 1, Pages 32–39


Inmaculada Moreno, Ph.D., Jason M. Franasiak, M.D., T.S. (A.B.B.)


Detection of bacteria with molecular techniques has enabled the study of low biomass microbiomes in tissues and organs previously considered sterile, such as the endometrium. Subsequently, an abnormal endometrial microbiota has been associated with implantation failure, pregnancy loss, and other gynecological and obstetrical conditions. Further investigation of the reproductive tract microbiome will allow for a better understanding of bacterial communities’ role in both physiology and pathophysiology, which in turn impacts the ability to achieve pregnancy and maintain a healthy pregnancy. Here we review the current literature that surrounds the endometrial microbiome and highlight the importance of assessing it as a future tool for improving reproductive outcomes in infertile patients.

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