Comparison of ectopic pregnancy risk among transfers of embryos vitrified on day 3, day 5, and day 6

Transfers of embryos vitrified on day 6 are associated with a significantly lower risk of ectopic pregnancy than both day-3 and day-5 vitrified embryo transfers.

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Volume 108, Issue 1, Pages 108–116.e1

Authors:

Tong Du, M.S., Hong Chen, M.D., Rong Fu, M.S., Qiuju Chen, Ph.D., Yun Wang, M.D., Ben W. Mol, M.D., Ph.D., Yanping Kuang, M.D., Qifeng Lyu, Ph.D.

Abstract:

Objective

To compare ectopic pregnancy risk among transfers of embryos vitrified on day 3, day 5, and day 6.

Design

Retrospective cohort study.

Setting

Academic tertiary-care medical center.

Patient(s)

A total of 10,736 pregnancies after 23,730 frozen-thawed embryo transfer (FET) cycles of in vitro fertilization/intracytoplasmic sperm injection from March 2003 to May 2015.

Intervention(s)

The ectopic pregnancy rate was compared among pregnancies resulting from transfers of embryos vitrified on day 3, day 5, and day 6. Generalized estimation equation regression models were used to calculate unadjusted and adjusted odds ratios and 95% confidence intervals for the association between ectopic pregnancy and selected patient and treatment characteristics. We studied this association in both the group that achieved pregnancy and the group that underwent an FET cycle.

Main Outcome Measure(s)

Odds of ectopic pregnancy.

Result(s)

The overall rate of ectopic pregnancy was 2.8% (304/10,736). Ectopic pregnancy rates after day-3, day-5, and day-6 vitrified embryo transfers were 3.1% (287/9,224), 2.0% (11/562), and 0.6% (6/950), respectively. After adjusting for confounders, the risks of ectopic pregnancy in day-3 and day-5 vitrified embryo transfers were both significantly higher than in day-6 vitrified embryo transfers. The associations were similar when we did calculations per cycle.

Conclusion(s)

In women undergoing FET, day-6 vitrified embryo transfer is associated with a significantly lower risk of ectopic pregnancy than both day-3 and day-5 vitrified embryo transfers.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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