Endometrial function: facts, urban legends, and an eye to the future

Human embryonic implantation is less efficient than in nonmenstruating species. The main difference lies in the decidual control of early implantation events and the subsequent course of pregnancy versus embryo control in nonmenstruating species.

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Volume 108, Issue 1, Pages 4–8

Authors:

Diana Valbuena, M.D., Ph.D., Cecilia T. Valdes, M.D., Carlos Simon, M.D., Ph.D.

Abstract:

The embryo alone, though very important, is not sufficient to explain successful or failed implantation. Human embryonic implantation is less efficient than in nonmenstruating species. The main difference lies in the decidual control of early implantation events and the subsequent course of pregnancy versus embryo control in nonmenstruating species. In this article, we introduce the facts behind the low efficiency of this crucial process, address urban legends routinely considered without high clinical quality evidence, and provide a vision of how the endometrial field will develop in the near future.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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