Urinary triclosan concentrations and diminished ovarian reserve among women undergoing treatment in a fertility clinic
Urinary triclosan concentrations were inversely associated with antral follicle count among a prospective cohort at an academic fertility center, an association stronger among younger and leaner women.
Volume 108, Issue 2, Pages 312–319
Lidia Mínguez-Alarcón, Ph.D., M.P.H., Georgios Christou, M.D., Carmen Messerlian, Ph.D., Paige L. Williams, Ph.D., Courtney C. Carignan, Ph.D., Irene Souter, M.D., Jennifer B. Ford, R.N., Antonia M. Calafat, Ph.D., Russ Hauser, M.D. for the show EARTH Study Team
To investigate the association between urinary triclosan concentrations and antral follicle count (AFC), a well-accepted marker of ovarian reserve, among women from a fertility center.
Prospective cohort study.
Hospital fertility center.
A total of 109 women.
Urinary triclosan concentrations quantified by online solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry.
Main Outcome Measure(s)
AFC through transvaginal ultrasonography on the third day of an unstimulated menstrual cycle or on the third day of a progesterone withdrawal bleed.
The geometric mean of the specific gravity–adjusted urinary triclosan concentrations for the 225 samples provided by the 109 women was 13.0 μg/L (95% confidence interval [CI], 8.9, 19.1). Women had median (with interquartile range) AFC of 13 (8, 18). The specific gravity–adjusted urinary triclosan concentrations were inversely associated with AFC (−4%; 95% CI, −7%, −1%). Women with triclosan concentrations above the median had lower AFC compared with those whose triclosan concentrations were equal to or below the median, with an adjusted difference of −3.2 (95% CI, −3.9, −1.6) among those with a body mass index <25 kg/m2 and −1.8 (95% CI, −3.2, −0.3) among those who were <35 years old.
Specific gravity–adjusted urinary triclosan concentrations were inversely associated with AFC in women seeking care at a fertility center. This association was modified by age and body mass index, with the younger and leaner women showing larger decreases in AFC.