Preimplantation genetic diagnosis for aneuploidy testing in women older than 44 years: a multicenter experience
Objective counseling is crucial in women 43 years requestingin vitro fertilization. Nevertheless, good ovarian reserve and preimplantation genetic diagnosis for aneuploidy may result in low miscarriage and good delivery rates in women aged 44.0-44.9 years.
Volume 107, Issue 5, Pages 1173–1180
Filippo Maria Ubaldi, M.D., M.Sc., Danilo Cimadomo, M.Sc., Antonio Capalbo, Ph.D., Alberto Vaiarelli, M.D., Ph.D., Laura Buffo, M.D., Elisabetta Trabucco, M.D., Susanna Ferrero, M.D., Elena Albani, M.Sc., Laura Rienzi, M.Sc., Paolo E. Levi Setti, M.D.
Extensive counseling based on biological and clinical data should be provided to women older than 43 years who are requesting IVF because of their very low odds of success and high risk for embryonic aneuploidies. Nevertheless, the low miscarriage and good delivery rates reported in this study in women with good ovarian reserve aged 44 should encourage the use of PGD-A in this population.