Intrinsic fertility of human oocytes
In a large natural cycle, single embryo transfer in vitro fertilization program, live baby rate per egg reveals the intrinsic fertility of the human oocyte without stimulation.
Volume 107, Issue 5, Pages 1232–1237
Sherman J. Silber, M.D., Keiichi Kato, M.D., Ph.D., Naoki Aoyama, M.Sc., Akiko Yabuuchi, Ph.D., Helen Skaletsky, Ph.D., Yuting Fan, M.D., Kazunori Shinohara, M.D., Noriyuki Yatabe, M.D., Ph.D., Tamotsu Kobayashi, M.D.
The intrinsic fertility per oocyte in natural cycle is far greater than reported in hyperstimulated cycles, varying robustly from 26% to 4% with age from <35 to 42 years. The curve is relatively flat until age 34, and then declines rapidly 10% per year thereafter.