Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility

A study of 107 infertile women identified 13 peritoneal fluid cytokines distinguishing women with or without endometriosis, indicating abberant Th1/Th2-activity, angiogenesis, and hematopoietic stem cell recruitment as possible pathogenetic mechanisms for endometriosis.

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Fertility and Sterility
Editorial Office, American Society for Reproductive Medicine
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Volume 107, Issue 5, Pages 1191–1199.e2

Authors:

Hilde Jørgensen, M.D., Abby S. Hill, B.S., Michael T. Beste, Ph.D., Manu P. Kumar, B.S., Evan Chiswick, Ph.D., Peter Fedorcsak, M.D., Ph.D., Keith B. Isaacson, M.D., Douglas A. Lauffenburger, Ph.D., Linda G. Griffith, Ph.D., Erik Qvigstad, M.D., Ph.D.

Abstract:

By combining univariate and multivariate analyses, profiles of cytokines more likely to be enriched or depleted in infertility patients with endometriosis compared with those without endometriosis were identified. These findings may inform future analyses of pathophysiological mechanisms of endometriosis in infertile patients, including dysregulated Th1/Th2 response and mobilization and proliferation of hematopoietic stem cells.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.