Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility
A study of 107 infertile women identified 13 peritoneal fluid cytokines distinguishing women with or without endometriosis, indicating abberant Th1/Th2-activity, angiogenesis, and hematopoietic stem cell recruitment as possible pathogenetic mechanisms for endometriosis.
Volume 107, Issue 5, Pages 1191–1199.e2
Hilde Jørgensen, M.D., Abby S. Hill, B.S., Michael T. Beste, Ph.D., Manu P. Kumar, B.S., Evan Chiswick, Ph.D., Peter Fedorcsak, M.D., Ph.D., Keith B. Isaacson, M.D., Douglas A. Lauffenburger, Ph.D., Linda G. Griffith, Ph.D., Erik Qvigstad, M.D., Ph.D.
By combining univariate and multivariate analyses, profiles of cytokines more likely to be enriched or depleted in infertility patients with endometriosis compared with those without endometriosis were identified. These findings may inform future analyses of pathophysiological mechanisms of endometriosis in infertile patients, including dysregulated Th1/Th2 response and mobilization and proliferation of hematopoietic stem cells.