A first-choice combined oral contraceptive influences general well-being in healthy women: a double-blind, randomized, placebo-controlled trial

A randomized, placebo-controlled trial on a firstchoice combined oral contraceptive found decreased general well-being but no statistically significant effect on depressive symptoms in healthy women.

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Volume 107, Issue 5, Pages 1238–1245

Authors:

Niklas Zethraeus, Ph.D., Anna Dreber, Ph.D., Eva Ranehill, Ph.D., Liselott Blomberg, B.Sc., Fernand Labrie, M.D., Ph.D., Bo von Schoultz, M.D., Ph.D., Magnus Johannesson, Ph.D., Angelica Lindén Hirschberg, M.D., Ph.D.

Abstract:

This study demonstrates a statistically significant reduction in general well-being by a first-choice OC in comparison with placebo in healthy women. We found no statistically significant effects on depressive symptoms. A reduction in general well-being should be of clinical importance.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.