A first-choice combined oral contraceptive influences general well-being in healthy women: a double-blind, randomized, placebo-controlled trial

A randomized, placebo-controlled trial on a firstchoice combined oral contraceptive found decreased general well-being but no statistically significant effect on depressive symptoms in healthy women.

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Volume 107, Issue 5, Pages 1238–1245


Niklas Zethraeus, Ph.D., Anna Dreber, Ph.D., Eva Ranehill, Ph.D., Liselott Blomberg, B.Sc., Fernand Labrie, M.D., Ph.D., Bo von Schoultz, M.D., Ph.D., Magnus Johannesson, Ph.D., Angelica Lindén Hirschberg, M.D., Ph.D.


This study demonstrates a statistically significant reduction in general well-being by a first-choice OC in comparison with placebo in healthy women. We found no statistically significant effects on depressive symptoms. A reduction in general well-being should be of clinical importance.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.